From Bottleneck to Breakthrough: Rethinking Downstream Processing with Single-Use Separation

As cell densities and titres continue to rise, harvest and clarification are increasingly becoming the limiting operations during scale-up and commercial manufacturing.

This webinar explores the emerging gap between upstream intensification and conventional clarification technologies. Through customer experiences, published industry studies and application work, we will discuss how CultureOne™ single-use disc-stack centrifugation enables robust harvest of highly intensified cultures at approximately 30 to 200 million CHO cells/mL (6–40% PCV) - while maintaining high product recovery, scalable performance and gentle product handling.

Speakers

You will hear from Aysha Kamran, Single-Use Separation Specialist at Alfa Laval, and Ivan Gitardi, Business Development Manager, Pharma, UK & Ireland. Together, they bring hands-on experience from single-use separation projects across biologics manufacturing and will share practical insights on what works, what to watch for, and how to successfully harvest intensified cell cultures.

Key learnings

• Why harvest and clarification are becoming the limiting steps in modern bioprocesses
• The practical challenges of processing cultures at approximately 30–200 million CHO cells/mL (6–40% PCV)
• How single-use disc-stack centrifugation bridges the gap between upstream intensification and conventional clarification
• How to achieve scalable harvest performance while maintaining high product recovery
• How gentle product handling protects product quality at high cell densities
• Insights from real customer applications and published industry studies

Is this webinar for you?

This session is designed for process development scientists, process engineers, downstream processing specialists, and professionals involved in biologics manufacturing, technology transfer, and scale-up. If you are looking for new ways to improve efficiency and flexibility in downstream operations, this webinar is for you.